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Histamine and the Brain (Histadelia)

What Histamine Does

 

Histamine is an excitatory neurotransmitter of the central nervous system in addition to its role in response to allergy and inflammation.

 

It appears that inherited histamine abnormalities in the brain are responsible for many mental problems.

High levels of histamine can cause agitation, irritability and sleep cycle disturbances. Low levels of histamine are associated with feeling tired.

 

Histamine is not just some vague body fluid that gets released in allergic reactions and causes sneezing, mucous, and swelling. It is quite remarkable what serious mischief this chemical can do. Inside the brain it has an important role, in all sorts of reactions.                                   

 

It causes our tears to flow, determines our pain sensitivity, and our sexual libido.                          

 

If brain levels get too low we become paranoid and suspicious, our ears may ring, and we may see or hear things abnormally. We will probably make grandiose plans but never have the energy to carry them out.

 

 

Signs and symptoms of histamine deficiency:

 

•           overactive mind

•           agitation

•           confusion

•           anxiety

•           memory loss

•           low libido

•           poor hearing

•           nausea

•           suppressed appetite

•           poor healing

 

How It Works in the Brain

 

In your hypothalamus, histamine stimulates the release of the important neurotransmitters serotonin, dopamine and norepinephrine.                                             

                         

The result of too low histamine can be thought disorders or even hallucinations that feel like your mind is playing tricks on you.

Other psychiatric symptoms develop when TOO MUCH histamine heightens and distorts the release of these key neurotransmitters serotonin, dopamine and norepinephrine.

 

When abnormally high, histamine will cause over stimulation, aggressiveness, compulsivity, and a racing brain (amongst other symptoms).

 

Histadelia:     

                                                                                                                 

Of the many biochemical imbalances that are sighted in the human race, abnormally high histamine levels (histadelia) has certainly caused the most frustration as well as monetary losses for those with the condition.

When brain histamine levels soar out of control, other frightening symptoms occur. The tendency to hyperactivity, compulsive behaviour and black depression increases as histamine rises abnormally.

 

Histadelics may grow obsessive about sex, have abnormal fears, compulsive rituals, cry easily and may even think about suicide often.

Many high-powered, energetic politicians and public figures show this high histamine combination of obsessive drive and high sexual libido. Without their abnormally high histamine, they would lack the stamina to fuel their careers so intensely. Unfortunately, their accompanying high sex drive is sometimes their undoing, despite being clever statesmen in every other way.

 

Typically these histadelic clients present for treatment when in high arousal about life in general. Being obsessive/compulsive people, they present for treatment expecting an instant fix.                                                                                                                                                                              

                                                                                                                                                                     

•  Usually they are seriously depressed and may even have suicide attempts in their own or their family’s history. 

•  They don't sleep much or well.  

•  They can cry at the drop of a hat and are terribly impulsive. 

•  Those who have tried drugs tend to get hooked on heroin or other narcotics and sometimes alcohol. All of these block           histamine and improve their symptoms temporarily.

•  Many have successful careers, fuelled by their remarkable drive and energy, but they are crumbling internally from continual tension and depression.

 

Typically, patients present with a pattern which, upon treatment, tends to repeat itself: Enthusiasm runs unrealistically high the first few days, but there is usually no staying power. Often before the first week is over, these clients impulsively lose interest, abandon their programs and return to drugs or pursue some new-found project down another road. These similar characteristics appear often.

 

One must intervene with treatment as soon as possible if it is hoped to hold their attention.  There are specific formulas for lowering histamine, (see later). These natural histamine blockers can invariably turn the tide. They make enough difference early on to thwart the impulsiveness of these people.

 

Early supplemental treatment intervention results in fewer failures with histadelic clients, and they become some of the most vocal supporters of these methods, once they are well. High histamine (histadelia) has a familial predisposition. Individuals with histadelia are often endowed with boundless energy and drive. They are aggressive, productive, Type A personalities who drive themselves obsessively toward attaining success. The large histamine pools they possess cause some of their brain neurotransmitters to run high and fire excessively.

 

This can result in some or all of the following conditions:

 

1.   Histadelics are often over stimulated, almost manic; their compulsive drives may lead them to alcohol which helps to alleviate their inner tension and afford them some peace of mind.

 

2.   Sleep is invariably a problem. They are light sleepers, usually needing seven or less hours. Insomnia can be severe. As they grow older, their need for sleep becomes even lower.

 

3.   If histamine levels get too high, phobias, compulsions and ‘blank periods’ or absent mindedness develop. They are the perfectionists and the "doers" who never seem to know how to relax. Histamine increases their cellular metabolism so their body temperature may be above normal and they metabolise their food quickly.If this is not the case, tests should be run to determine thyroid gland efficiency.Typically histadelics have no problem with weight gain. If there is a weight problem, it is coming from food and chemical allergies that set off hunger, or binging, or from subclinical hypothyroidism.Upon identification and avoidance of these allergic triggers and or correction of any underlying thyroid abnormality, histadelics will slowly lose unwanted body weight (this process may take a full year) and recover the natural high energy levels that their allergies were masking.

 

4.   Because of their elevated metabolic rate and higher body temperature, their bodies develop anatomically to help dissipate the extra heat: ears, nose, hands and feet may be enlarged. Fingers and toes are usually long. In a histadelic, the second toe is frequently longer than the big toe. They can also have very little facial and chest hair, again helping to promote more rapid loss of extra body heat. (These are the individuals who keep turning down the thermostat!)

 

5.   Suicidal depression puts these people at high risk because they have the energy to carry out a suicide plan and the impulsiveness to act quickly without thinking it over. Not all histadelics are depressed. It is not known why some have depression and others do not.

 

6.   Since histamine produces an abundant production of fluid secretions, histadelics have an overproduction of saliva that keeps their teeth free of cavities. (Sometimes, saliva is literally dripping from the corners of their mouth). Sexual orgasms are easy in females because of their increased mucous. In males, this mucous is internal and accounts for assisting the smaller, faster male sperm to win the race to fertilize the egg, so high histamine families produce mostly male children.

 

7.   Most histadelics have a very low pain threshold and will over-react to pain. They often complain of pain. Headaches and respiratory allergies are common.

Histadelia is more common in males and is characterized by low levels of serotonin, dopamine, and norepinephrine, high blood histamine and elevated basophils (a type of white blood cell).

 

Histamine is stored in mast cells and basophils - the cells participating in the immune response.

It is estimated that 15-20% of schizophrenics are probably histadelic.
This is a disorder in direct contrast to histapenia in which case there is too little histamine.

 

Family Tendencies

 

Histadelic characteristics are seen within families and invariably, family members possess a tremendous, unrelenting passion to attain. This is often rewarded by the visible trappings of wealth and success, but the dark side of these brilliant strivers is also seen - their compulsive risk taking often ends in tragedy. Sometimes, their wild sexual exploitations can compromise their reputations. Their high tolerance for alcohol and drugs can sometimes end in mayhem, death or even suicide.

It is often seen as a declining tendency in families, with each new generation showing continuing decline as a result of the deteriorating status of their brain chemistry as alcohol, drugs and the stresses of life deplete them.

Drugs and Alcohol Attract Many Histadelics

 

These obsessive, driven people are invariably attracted to drugs, often using cocaine, crack, ‘ice’, amphetamines or high quantities of caffeine and sugar to further stimulate them. All they are trying to do is to lift the chronic black depression that does not respond well to antidepressants. The trick is to lower the histamine resulting in the depression simply fading away.

Many high level histadelics end up as drug addicts, discovering that opiates (heroin, morphine, opium, codeine), which are strong histamine releasers, make them feel better temporarily.

Alcohol also has some histamine-reducing action and so histadelics often become alcoholics and can handle huge quantities of alcohol without a hangover.

 

They often present for treatment suffering from many physical complaints such as joint pain, headaches, hay fever and stomach aches.          

                                                                                      

Histadelics often seek psychological assistance for their inner turmoil but the problem is a chemical one and talk therapy changes nothing. Correction of the problem has to occur BIOCHEMICALLY first.

 

The High Histamine Child

 

Most histadelic children are very self-motivated and achievement-oriented. However, some are so self-directed that they resent giving up their control to a parent or teacher. They can't stand being told what to do by adults. These youngsters become disruptive within their families and classrooms. Physical discipline only causes their behaviour to intensify. They may not easily make friends with their peers, preferring much younger children or adults. If counselling is pushed, it typically will be a failure.

 

A diagnosis of "oppositional defiant disorder" often results. These children tend to get obsessively hooked on activities. This can be advantageous to the child who pursues learning or sports, but will present problems if the focus is on negative activities like playing video games excessively.

 

Histadelic children often exhibit certain characteristics: overabundant energy, always active with their bedroom being unbelievably neat and orderly.

 

They often eat continually, but can be lean and lanky (rapid metabolism). Their teeth are often in excellent shape due to increased saliva.

They are invariably perfectionists who are very creative.

So there are warnings signs that the ordinary brochures about suicide don't mention.

 

The most likely candidates are the compulsive, depressed histadelic kids and adults.

Drug use among histadelic teenagers is five times more likely than with histapenic (low histamine) young people. These drugs steadily worsen their nervous system imbalances.  

 

If they start smoking cigarettes, they may become chain-smokers. It is important to channel their obsessive-compulsive tendencies into productive activities.

 

If it is suspected that a child fits this category, a blood test will be able to correctly pinpoint their histamine levels.

 

 

For treatment, no drugs are required to lower histamine; it is best achieved by correcting the diet and by taking appropriate supplementation. 

 

To have high-normal histamine levels in a child can be a great advantage. The natural energy and drive to succeed in life seen in these children gives them a competitive edge, but it must be directed. The danger lies in letting histamine rise to such high levels that there is suicidal depression or impulsive sexual addiction or obsessions that are uncontrollable.

Sexual Addiction

 

The high libido of the histadelic seems bound to set them up for trouble. Being loyal to one partner is a big order for someone who is addicted to the joys of sex. Histadelics often succumb to their compulsion to pick up a prostitute, or cruise porno bookstores and peep shows, and can easily become voyeurs. They claim this addiction is not unlike alcohol or drugs, which seems to build up, the longer they try to abstain. Finally, there is a period of binging on these activities and this behaviour invariably gets them into trouble with the law. Others simply have multiple affairs. The employee who is sexually harassing co-workers through inappropriate touching or sexual language, may be suffering from a sexual addiction. Modifying this out-of-control histadelic libido is best achieved by simply lowering the histamine levels.

 

Suicidal Depression

 

Out of control histamine levels lead to serious depression in about one-half of histadelics.

Histadelics often may have several suicides in their genetic family history. The depression that plagues such people, does not respond well to anti-depressants and not at all to electro-convulsive (shock) therapy. An early diagnosis of excessive histamine is important to safeguard them against their own compulsivity and to deal with their inner tensions by attempting suicide to end their life.  The table below shows that with treatment, depression is often lifted quickly, but compulsions with abnormal fears are the most difficult to treat, and the last symptoms to go.

 

In severe cases involving psychosis, the dominant symptom is usually delusional thinking rather than hallucinations. 

Even in milder cases, delusion can still play a key role – the affected individual experiencing a surreal world of grandiosity and delusion without a clue that what they are experiencing has little bearing on the reality of a situation. The tendency is more often seen by observers rather than by the individual themselves. Histadelics tend to speak very little & may sit motionless for extended periods. They may appear outwardly calm, but suffer from extreme internal anxiety.

They have addictive tendencies with a high incidence of alcoholism, drug abuse, anorexia, and bulimia. They often are diagnosed with seasonal affective disorder (SAD) which is most serious during autumn and winter.

Recovery


The treatment of histadelia requires great patience because six to ten weeks are often needed before the beginning of significant improvement. The treatment usually takes twelve months to complete.
Nutritional supplementation can correct the disordered chemistry of conduct disorder & ODD (oppositional-defiant disorder) in children & teens.

 

It has been learned that older patients can have a rotten self-image and terrible social habits, which persist even if the original cause of the behaviour disorder is eliminated. They usually profit greatly from quality counselling, once the chemistry is rectified.

It has been observed that counselling is often unsuccessful until the "edge" of the OCD tendency is overcome with nutritional therapy, but thereafter quality counselling can be helpful. 

 

Histamine and diet

Avoid a high protein diet as most proteins contain histidine, the amino acid from which can be synthesized even more histamine and thereby increase depression. A preferable diet is one high in vegetables and fruits.

 

Treatment

 

Generally, these patients respond nicely to methionine, vitamin C, SAMe, calcium, magnesium, B6, inositol, TMG, and zinc.

Most histadelic patients get worse if given supplements of DMAE, choline, copper, or folic acid.

Methionine supplementation lowers blood levels of histamine by increasing histamine breakdown. Typical dose is a 500 mg capsule taken four times daily. Calcium, taken in the form of calcium salts reduces the release of the body’s store of histamine and lowers levels in the body.

Zinc and manganese aid the calcium-methionine program and provide additional relief. With magnesium, it acts as a natural tranquilizer. The amino acids l-tyrosine and l-tryptophan boost norepinephrine and dopamine levels respectively, also helping to alleviate depression.

 

A study has established that tryptophan and its co-enzymes vitamin C and vitamin B6, stabilized obsessive-compulsive patients within six months by using tryptophan to increase serotonin, the brain's calming neurotransmitter. The B vitamin, inositol, effectively eliminates symptoms of obsessive-compulsive disorder over a six week period, and has absolutely no detrimental side effects. Inositol works by regulating the action of serotonin within the nerve cells. It has a soothing effect on spinal-cord nerves, the brain and cerebrospinal fluid, and produces anti-anxiety effects. A dose of 500 to 1000 mg/day of inositol will probably be needed to provide good response.

 

Histadelics also benefit from raising depleted levels of acetylcholine in their brain. Taking the precursor, phosphatidyl choline can help to achieve this. Acetylcholine stabilizes brain membranes, greatly improves mood, and restores short-term memory. Taking multivitamins or B-complex vitamins that contain folic acid and B12 should be avoided as both increase body stores of histamine and increase depression.It is beneficial however, to take the other B vitamins separately, as they play a huge role in stabilizing the nervous system. Foods containing folate and histidine are unacceptable for histadelics.

  

 

Foods which contain methionine:

  • Chicken                                  

  • Beef                                        

  • Fish                                               

  • Eggs                                              

  • Cottage Cheese                                    

  • Liver                                                  

  • Soybeans                                

  • Soy Protein                             

  • Milk                                              

  • Ham, pork                        

  • Yoghurt                                  

  • Sardines                                  

Foods which contain calcium:

  • Collard Greens                         

  • Turnip Greens                         

  • Dandelion Greens                                                             

  • Almonds                                 

  • Parsley                                    

  • Corn Tortillas                               

  • Watercress                         

  • Buttermilk                               

  • Yoghurt                                        

  • Beet Greens                                   

  • Buckwheat                                   

  • Sesame Seeds                         

  • Broccoli                                  

  • Walnuts                                  

  • Cottage Cheese                             

  • Spinach                                          

  • Pecan Nuts                             

  • Romaine Lettuce                     

  • Swedes                                       

  • Green Beans                          

  • Globe Artichokes                          

  • Dry Beans                               

  • Cabbage                                  

  • Bean Sprouts                              

  • Whole Grain Wheat

Foods which contain magnesium:

  • Almonds                                 

  • Buckwheat                              

  • Filbert Nuts                                  

  • Millet                                              

  • Whole Grain Wheat                

  • Pecan Nuts                              

  • Walnuts                                   

  • Whole Grain Rye                   

  • Beet Greens                            

  • Spinach                                   

  • Brown Rice                             

  • Swiss Chard                               

  • Collard Greens                                 

  • Prawns                                               

  • Corn                                       

  • Avocado                                 

  • Parsley                                    

  • Dry Beans                               

  • Barley                                     

  • Dandelion Greens                   

  • Garlic                                       

  • Green Peas                                   

  • Jacket Potatoes                                    

  • Crab                                        

  • Banana                                               

  • Sweet Potatoes                         

  • Blackberries                                 

  • Beets                                            

  • Broccoli                                  

  • Cauliflower                                 

  • Carrots                                           

  • Celery                                     

  • Asparagus                                         

  • Turkey                                      

  • Chicken                                  

  • Green Peppers                                  

  • Squash                                      

  • Cantaloupe                             

  • Eggplant                                          

  • Tomato                                                

  • Cabbage                                 

  • Grapes                                            

  • Skim Milk                                   

  • Pineapple                                

  • Mushrooms                               

  • Onions                                              

  • Oranges                                  

  • Plums                                        

  • Apples

Foods which contain Vitamin B6 (Pyridoxine):

  • Chicken                                  

  • Beef                                        

  • Kidney                                       

  • Tuna                                    

  • Walnuts                                  

  • Salmon                                         

  • Trout                                              

  • Lentils                                     

  • Lima Beans                                     

  • Buckwheat                                 

  • Black-eyed Peas                     

  • Navy Beans                                   

  • Brown Rice                                   

  • Hazelnuts                                

  • Garbanzos                                       

  •  Pinto Beans                             

  • Bananas                                  

  • Albacore Tuna                            

  • Halibut                                           

  • Avocados                               

  • Whole Grain Wheat                          

  • Chestnuts                                  

  • Kale                                        

  • Whole Grain Rye                           

  • Spinach                                        

  • Turnip Greens                        

  • Sweet Red Peppers                                

  • Potatoes                               

  • Sardines                                  

  • Brussel Sprouts                                

  • Perch                                         

  • Cod                                         

  • Barley                                          

  • Sweet Potatoes                         

  • Cauliflower                            

  • Red Cabbage                                  

  • Leeks

Foods which contain inositol:

  • Brewer’s Yeast                                    

  • Wheat Germ (fresh)               

  • Lecithin                                   

  • Whole Grains                         

  • Oatmeal                                  

  • Corn                                            

  • Nuts (raw, unsalted)            

  • Milk                                        

  • Molasses                                    

  • Citrus Fruits                         

  • Liver

Foods which contain zinc:

  • Oysters                                                

  • Ginger Root                           

  • Pecans                                          

  • Split Peas                           

  • Whole Grain Wheat                

  • Whole Grain Rye                           

  • Oats                                             

  • Lima Beans                             

  • Almonds                                 

  • Walnuts                                   

  • Sardines                                  

  • Turkey                                            

  • Chicken                          

  • Buckwheat                              

  • Hazel Nuts                                           

  • Clams                                     

  • Tuna                                       

  • Haddock                                           

  • Green Peas                               

  • Prawns                                    

  • Turnips                                        

  • Black Pepper    (high)              

  • Paprika   (high)                                    

  • Dry Mustard  (high)                                   

  • Chili Powder     (high)              

  • Thyme    (high)                                    

  • Cinnamon    (high)

Foods to avoid:

 

Foods which contain choline:

  • Egg Yolk                                 

  • Brewer’s Yeast                                    

  • Lecithin                                                 

  • Beef Liver                           

  • Lettuce                                    

  • Legumes                                                          

  • Whole grains                           

  • Cauliflower                             

  • Peanuts                                                      

  • Grape juice                                  

  • Soybeans                                

 Foods which contain copper:

  • Liver                                       

  • Heart                                       

  • Eggs                                                 

  • Brewer’s Yeast                            

  • Almonds                                

  • Peas                                                     

  • Green Leafy Vegetables                    

  • Whole Grains                          

  • Prunes                                                

  • Raisins                                    

  • Pomegranates

Foods which contain folic acid:

  • Chicken Liver                         

  • Beef Liver                              

  • Wheat Germ                                        

  • Asparagus                              

  • Lettuce                                    

  • Dark Green Leafy Vegetables           

  • Spinach                                     

  • Orange Juice                           

  • Legumes                                         

  • Broccoli                          

  • Irish Potatoes                          

  • Nuts (raw, unsalted)

  

As can be seen in these foods, there can be considerable overlap with those foods containing necessary nutrients and those which should be avoided. Self assessment can be achieved by eating a particular food and assessing any mood swings over the next 24 hours, or simply contact the Total Health Clinic for your Histamine Testing kit.

 

 

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